【摘要】目的 探讨眩晕患者的情绪因素与眩晕发作之间的关系，以及眩晕患者鼓室庆大霉素注射术后生活质量的改变。方法 回顾性调查在我院就诊并行鼓室庆大霉素注射治疗后的17例顽固性周围性眩晕患者和正常对照20例，参与者分别应用医院焦虑抑郁量表(HADS)，焦虑自评量表(SAS)，抑郁自评量表(SDS)，症状自评量表(SCL-90)进行测评。比较眩晕患者与正常人之间以及眩晕患者自身术前、术后的得分差异。并使用梅尼埃病治疗效果问卷（MDOQ）对17例眩晕患者的术后生活质量情况进行调查。结果 眩晕患者HAD、SAS、SDS及SCL-90量表总分均明显高于对照组（P<0.01）。眩晕患者鼓室庆大霉素注射术前的HAD、SAS、SDS及SCL-90量表总分与术后相比均有明显差异（P<0.05）。所有问卷男性与女性相比均未见显著性差异（P>0.05）。眩晕患者术后QOL得分总的变化为40.1分（P<0.01），QOL得分与MDOQ得分有很密切的关系（P<0.05）。结论 眩晕患者在心理评定量表中的多项因子与正常人有显著差异，提示多种精神心理因素与眩晕发作有关。鼓室庆大霉素术后的眩晕患者其生活质量得到明显改善。
   【关键词】 眩晕； 前庭功能障碍；焦虑；情绪障碍；生活质量

【Abstract】 Objective  To investigate the relationship between psychological disorder and vestibular dysfunction in patients suffering from vertigo, and to measure patients’ quality of life after intratympanic gentamicin surgery. Method  Retrospective study of 17 patients with peripheral vestibular dysfunction recruited from the EENT hospital whom underwent intratympanic gentamicin injection. Hospital Anxiety and Depression scale, Self-rating Anxiety scale, Self-rating Depression scale, Symptom Checklist-90 were used. Pre- and postoperative scores where compared. The QOL of the 17 vertiginous patients were assessed with the Meniere’s Disease Outcome Questionnaire. Results The outcomes of Hospital Anxiety and Depression scale, Self-rating Anxiety scale, Self-rating Depression scale, Symptom Checklist-90 are significantly greater in vertiginous group than that in normal controls（P<0.01）. The preoperative scores of these 4 questionnaires are greater than the postoperative scores in vertiginous patients（P<0.05）. No significant difference was noted between male and female participants in all the questionnaires used（P>0.05）. Overall, the mean change in QOL score was 40.1points（P<0.01）, the change in Meniere’s Disease Outcome Questionnaire quality-of-life score was highly correlated with that of the global question score（P<0.05）.Conclusion  Significant differences were noted between vertiginous patients and normal controls in psychiatric questionnaires, suggesting that psychological dysfunction may contribute to the vertigo episode. Vertiginous patients’ quality of life have significant improvement after intratympanic gentamicin surgery.  
【Key Words】 vertigo; vestibular dysfunction; anxiety; psychiatric disorders; quality of life